P-Stereogenic Phosphines Prepared by Enantioselective Deprotonation
This chapter describes the preparation of P-stereogenic phosphines by enantioselective deprotonation and electrophilic quenching of precursors bearing certain enantio- or diastereotopic groups. Most of the chapter is devoted to the deprotonation with s-BuLi/(–)-sparteine as a chiral organolithium reagent. Dimethylphosphine-boranes and sulfides are considered in the first section whereas the second one deals with deprotonation of phosphetanes, phospholanes and phosphorinanes. A third section with extensions of the basic method with other chiral bases and substrates closes the chapter.