Jump to main content
Jump to site search

All chapters
Previous chapter Next chapter

Chapter 5

P-Stereogenic Phosphines Prepared by Enantioselective Deprotonation

This chapter describes the preparation of P-stereogenic phosphines by enantioselective deprotonation and electrophilic quenching of precursors bearing certain enantio- or diastereotopic groups. Most of the chapter is devoted to the deprotonation with s-BuLi/(–)-sparteine as a chiral organolithium reagent. Dimethylphosphine-boranes and sulfides are considered in the first section whereas the second one deals with deprotonation of phosphetanes, phospholanes and phosphorinanes. A third section with extensions of the basic method with other chiral bases and substrates closes the chapter.

Publication details


Print publication date
20 Dec 2010
Copyright year
2011
Print ISBN
978-1-84973-123-2
PDF eISBN
978-1-84973-270-3
From the book series:
Catalysis Series