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Chapter 8

Multiple Roles of Glycogen Synthase Kinase-3 in Alzheimer's Disease

One of the most notable developments in research concerning Alzheimer's disease is the solid evidence directly linking glycogen synthase kinase-3 (GSK-3) to most, if not all, of the major mechanisms known to contribute to the neuropathology of the disease. GSK-3 interacts with multiple components of the plaque-producing amyloid system associated with Alzheimer's disease. GSK-3 participates in phosphorylating the microtubule-binding protein tau, which may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. GSK-3 interacts with presenilin and other Alzheimer's disease-associated proteins. GSK-3 has a central role in neuronal plasticity and memory. GSK-3 promotes both inflammation and apoptosis. These many links between GSK-3 and Alzheimer's disease are discussed in this chapter.

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07 May 2010
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From the book series:
Drug Discovery