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Chapter 1

The Amyloid Hypothesis of Alzheimer's Disease and Prospects for Therapeutics

Evidence from pathology, genetics, biochemistry, molecular biology, cell biology and animal models strongly supports the amyloid hypothesis of Alzheimer pathogenesis, in which aggregated forms of the amyloid β-protein (Aβ) initiate a cascade leading to neurotoxicity and neurodegeneration. The challenge now is to translate this knowledge into practical therapeutics for prevention and treatment. Various strategies aimed at lowering Aβ levels, blocking Aβ aggregation or otherwise clearing this neurotoxic protein from the brain will be discussed and will include selected examples of agents in clinical trials, along with comment on their problems and promise.

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07 May 2010
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From the book series:
Drug Discovery