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Regulation of Metallothionein Gene Expression

Organisms from bacteria to humans use elaborate systems to regulate levels of bioavailable zinc, copper, and other essential metals. An excess of them, or even traces of non-essential metals such as cadmium and mercury, can be highly toxic. Metallothioneins (MTs), short, cysteine-rich proteins, play pivotal roles in metal homeostasis and detoxification. With their sulfhydryl groups they avidly bind toxic metals and also play a role in cellular redox balance and radical scavenging. The intracellular concentration of MTs is adjusted to cellular demand primarily via regulated transcription. Especially upon heavy metal load, metallothionein gene transcription is strongly induced. From insects to mammals, the major regulator of MT transcription is MTF-1 (metal-responsive transcription factor 1), a zinc finger protein that binds to specific DNA sequence motifs (MREs) in the promoters of MT genes and other metal-regulated genes. This chapter provides an overview of our current knowledge on the expression and regulation of MT genes in higher eukaryotes, with some reference also to fungi which apparently have independently evolved their own regulatory systems.

Publication details


Print publication date
19 Jan 2009
Copyright year
2009
Print ISBN
978-1-84755-899-2
PDF eISBN
978-1-84755-953-1
From the book series:
Metal Ions in Life Sciences