Metallothioneins: Historical Development and Overview
The history on research of metallothionein is reviewed. Various methods for isolation, characterization, and quantification are evaluated. The role of metallothionein in metal metabolism and toxicity is explained. Gender differences and polymorphism as well as possible relationships with diseases are discussed. The review is based on data from the literature and on own original experimental and epidemiological data. Aspects on future research within the metallothionein field are indicated.