Exploring the unique properties of nano-systems is the new frontier in science. Their amazing size and shape dependent chemistry and physics provide evidence for tremendous advantages to gain, and challenges to face. In his famous book, Consilience; the unity of knowledge, E. O. Wilson argued that all human being intellectual products are explainable in terms of physics, chemistry, and biology, and could eventually be unified based on scientific foundations. The mounting evidences that chemistry, biology, and physics seem to be unified at the nano-scale make it plausible to predict that all human knowledge could eventually be explained along the notion of nanophenomena. Harnessing and directing the power of nanotechnology towards human prosperity is the main challenge to face.