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Chapter 21

DNA Damage Leads to Neurodegeneration via Mitochondrial Dysfunction

Neurodegeneration results in devastating illnesses with few effective treatments. Mitochondrial dysfunction has been associated with several neurodegenerative diseases. Neurons are highly energetic cells and rely heavily on healthy mitochondria. Much recent work has focused on the causes of mitochondrial dysfunction and resulting diseases. This chapter details how DNA damage results in mitochondrial dysfunction by nuclear to mitochondrial signaling or direct mitochondrial DNA damage. It also reviews current literature about neurodegenerative disease and its relationship to DNA damage and repair.

Publication details

Print publication date
18 Nov 2020
Copyright year
2021
Print ISBN
978-1-83916-251-0
PDF eISBN
978-1-83916-254-1
ePub eISBN
978-1-83916-256-5

From the book series:
Chemical Biology