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Chapter 20

Fidelity Mechanisms of DNA Polymerase Beta

DNA polymerase β functions in DNA repair and has been extensively characterized as a model enzyme in order to ascertain the molecular mechanisms of DNA polymerase catalysis and fidelity. Research on the catalytic mechanism of polymerase β with a particular emphasis on substrate specificity is reviewed here. Notably, phosphodiester bond formation is the rate-limiting step of the reaction. Recent work has also provided strong evidence for an induced fit mechanism underlying correct selection of the nucleotide substrate for incorporation into DNA.

Publication details

Print publication date
18 Nov 2020
Copyright year
2021
Print ISBN
978-1-83916-251-0
PDF eISBN
978-1-83916-254-1
ePub eISBN
978-1-83916-256-5

From the book series:
Chemical Biology