Mechanisms and Maps of Nucleotide Excision Repair
Nucleotide excision repair is a process by which bulky adducts are excised from the genome and released in small, single-stranded DNA fragments with subsequent repair synthesis and ligation. This process is essential for removing DNA damage caused by exposure to sources such as UV light, platinum-based chemotherapies, and cigarette smoke. Novel methods have enabled us to map these damage and repair events at single-nucleotide resolution. Repair deficiencies can lead to mutations and subsequent tumorigenesis. Additionally, alterations in repair may impact response to commonly used chemotherapies.