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Chapter 16

Mechanisms and Maps of Nucleotide Excision Repair

Nucleotide excision repair is a process by which bulky adducts are excised from the genome and released in small, single-stranded DNA fragments with subsequent repair synthesis and ligation. This process is essential for removing DNA damage caused by exposure to sources such as UV light, platinum-based chemotherapies, and cigarette smoke. Novel methods have enabled us to map these damage and repair events at single-nucleotide resolution. Repair deficiencies can lead to mutations and subsequent tumorigenesis. Additionally, alterations in repair may impact response to commonly used chemotherapies.

Publication details

Print publication date
18 Nov 2020
Copyright year
2021
Print ISBN
978-1-83916-251-0
PDF eISBN
978-1-83916-254-1
ePub eISBN
978-1-83916-256-5

From the book series:
Chemical Biology