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Chapter 8

Functionalized Magnetic Nanoparticles for Solid-phase Extraction

Superparamagnetic nanosized particles, whose surfaces are functionalized with several site-specific polymers, ligands, peptides and antibodies are used as sorbent materials in the isolation of analytes from a variety of solution matrices by exerting a magnetic force with an application; the so-called magnetic solid phase extraction (MSPE). In the two decades since the first application of MPSE, various experimental strategies have been introduced employing numerous combinations of MNPs (transition metals such as Fe, Ni, Co; metal oxides MFe2O4 with M: Mn, Zn, Ni, Co and metallic alloys like FePt, and CoPt) with very different types of coating materials such as octadecylsilane, layered double hydroxide, β-cyclodextrine, carbonaceous nanomaterials (like graphene, graphene oxide and carbon nanotubes), dendrimers, molecularly imprinted polymers, ionic liquids and metal organic frameworks. In this review, the most common approaches and recent advances in MSPE applications will be summarized within the perspective of how the application efficiency depends on the physico-chemical and surface properties of MNPs.

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04 Aug 2021
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