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Chapter 7

Ion Mobility–Time-of-flight Mass Spectrometry and Applications for Metabolomics

Applications of ion mobility (IM) coupled to high-resolution mass spectrometry, i.e., quadrupole time-of-flight (QTOF) instruments, have experienced a significant growth in recent years, especially in the ‘omics fields including metabolomics. Several types of instrumental platforms are now commercially available and exploit different operation principles for the IM separation. In this contribution, we discuss the current state of commercial IM–QTOFMS technology and data acquisition strategies relevant to metabolomics studies. Particular focus is placed on the strengths and weaknesses of the application of this technology both for data generation and emerging strategies and opportunities within data processing workflows that take full advantage of the added IM dimension.

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21 Jul 2021
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