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Chapter 1

Translational Motion of Water in Biological Tissues – A Brief Primer

As an introduction to the rigorous treatment of diffusion encoding in the rest of the book, this chapter gives simple non-mathematical explanations of the relations between the properties of biological tissues and the translational motion of the tissue water with the aim of conveying an intuitive feel of the relevant time and length scales and the level of detail of the information that can be obtained. The influence of biomembranes and macromolecules on water dynamics is reviewed from both molecular and cellular scale perspectives. The potentially complex motion patterns are decomposed into short-time diffusivity, restriction, anisotropy, flow, and exchange, which can be independently assessed and correlated with advanced diffusion encoding methods in MRI.

Publication details

Print publication date
11 Aug 2020
Copyright year
Print ISBN
ePub eISBN

From the book series:
New Developments in NMR