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Chapter 5

In Situ Analysis of the Intracellular Caspase Family

Caspases, the central molecular initiators and executors of apoptosis, are a family of cysteine–aspartic proteases. Because of the central position of caspases in apoptosis pathways, activated caspases are well-established targets of choice for the detection of cell death both in vitro and in vivo or evaluation of the therapeutic effect of a treatment. In vivo imaging of cell apoptosis can provide remarkable advantages in the diagnosis and treatment of disease. This chapter covers the latest imaging strategies for the intracellular caspase family and also some duplex imaging methods that can simultaneously light up caspase and other proteins. Moreover, tracking methods for caspase cascade activation are also discussed.

Publication details


Print publication date
28 Jan 2020
Copyright year
2020
Print ISBN
978-1-78801-722-0
PDF eISBN
978-1-83916-045-5
ePub eISBN
978-1-83916-135-3
From the book series:
Detection Science