Jump to main content
Jump to site search

All chapters
Previous chapter Next chapter

CHAPTER 8

Emerging Role of CXCR4 in Fibrosis

Recent evidence has shown that the chemokine receptor CXCR4 and its natural chemokine ligand CXCL12 promote pro-inflammatory responses in a variety of situations and this axis has emerged as a central player in tissue fibrosis. Although its role as a co-receptor for human immunodeficiency virus (HIV) and a key player in various cancers has been well established, the role of CXCR4 in various types of fibrosis has emerged only recently. This review will explore the involvement of CXCR4 in the development of fibrosis, focusing mainly on lung, kidney and eye fibrosis.

Publication details


Print publication date
03 Mar 2020
Copyright year
2020
Print ISBN
978-1-78801-510-3
PDF eISBN
978-1-78801-578-3
ePub eISBN
978-1-83916-051-6
From the book series:
Drug Discovery