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Coffee and Alzheimer's Disease

Alzheimer's disease (AD) is the most prevalent form of dementia in the aged population. Definitive diagnosis of AD is based on the presence of senile plaques and neurofibrillary tangles that are identified in post-mortem brain specimens. The formation of AD specific lesions is attributed to the pathological accumulation of either extracellular amyloid beta peptide or intraneuronal hyperphosphorylated Tau protein. Constituents of the lesions are prone to promote synaptic deficits leading to memory impairments. However, besides targeting lesions, other pathways may be of interest to control, such as inflammatory processes. In this review, we will emphasize the current data supporting the beneficial impact of coffee and constituents in Alzheimer's disease and presumable underlying mechanisms.

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31 Jan 2019
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