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CHAPTER 3

Preparation of Cultured Cell-derived Decellularized Matrix (dECM) – Factors Influencing dECM Formation and Its Ability

There are two types of decellularized extracellular matrix (dECM): tissue- or organ-derived dECM and cultured cell-derived dECM. Although it is difficult to prepare cultured cell-derived dECM, which is completely the same as the native extracellular matrix (ECM), it has several advantages over tissue- or organ-derived dECM. Thus, cultured cell-derived dECM has been developed for various purposes. This chapter summarizes the points that need to be considered for the preparation and assessment of cell-derived dECM, after a brief summary of the ECM formation processes. The applications of cultured cell-derived dECM are then briefly reviewed. Finally, the problems to be solved in the future for the progress of cultured cell-derived dECM technology are described.

Publication details

https://doi.org/10.1039/9781788015998-00029
Print publication date
11 Dec 2019
Copyright year
2020
Print ISBN
978-1-78801-467-0
PDF eISBN
978-1-78801-599-8
ePub eISBN
978-1-83916-126-1
From the book series:
Biomaterials Science Series