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CHAPTER 6

Progressive Multiple Sclerosis: Drug Discovery

The disease-modifying therapies approved to treat relapsing–remitting multiple sclerosis (MS) are less effective in patients with progressive disease, with benefit largely limited to patients with recent inflammatory disease activity. Novel treatment approaches such as neuroprotective agents and repair-promoting strategies are needed to treat progressive disease, which appears to result from more compartmentalized inflammation, diffuse tissue damage, and neurodegeneration. The development of effective therapeutic strategies for progressive MS will require sensitive methods to quantify disability and detect ongoing worsening or improvement and better understanding of the pathogenesis of progression.

Publication details


Print publication date
28 Jun 2019
Copyright year
2019
Print ISBN
978-1-78801-450-2
PDF eISBN
978-1-78801-607-0
ePub eISBN
978-1-78801-806-7
From the book series:
Drug Discovery