Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

All chapters
Previous chapter Next chapter

Chapter 14

Formulations of Microspheres and Nanoparticles for Peptide Delivery

Delivery of peptide drugs using microspheres has been used in a number of commercial drug formulations and this area continues to grow to overcome potential challenges with the intrinsic properties of peptides and proteins. The use of microparticles as an alternative delivery system for peptide and protein drugs has attracted substantial interest in recent years. Encapsulation of peptides or proteins in such carrier systems during formulation could potentially benefit the drug profile. Several examples of peptide and protein delivery using microsphere formulations are included. Different types of microspheres, their preparation, characterization, factors affecting drug delivery and mechanism of drug delivery are discussed. Peptide drugs on the market such as leuprolide, triptorelin, octreotide, lanreotide, human growth hormone, buserelin, abarelix and exenatide use microsphere-based formulations. Drug nanoparticle formulations have been demonstrated to show increased solubility and thus enhanced bioavailability, with additional ability to cross the blood–brain barrier, enter the pulmonary system and be absorbed through the tight junctions of endothelial cells of the skin, primarily owing to their small size and large surface area. Nanoparticle formulations based on liposomes, polymeric micelles, polymeric nanoparticles, nanoemulsions, nanogels, dendrimers, fullerenes, carbon nanotubes, magnetic nanoparticles, metal nanoparticles and quantum dots have been extensively discussed in the literature. Selected examples of peptide/protein nanoparticle formulations are discussed with special emphasis on various delivery routes and delivery mechanisms.

Publication details

Print publication date
28 Aug 2019
Copyright year
Print ISBN
ePub eISBN
From the book series:
Drug Discovery