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Chapter 5

Peptide Manufacturing Methods and Challenges

Peptides are manufactured commercially by liquid- or solid-phase peptide synthesis, by hybrid synthesis using both solid- and solution-phase synthesis or by using recombinant DNA technologies. The technology applied to commercial manufacturing is determined by the size and nature of the peptide. Since the impurities in peptides tend to be generally similar to those in the product of interest, downstream processing steps such as purification and isolation are significant for producing highly purified active peptide pharmaceutical ingredients that meet the stringent regulatory requirements.

Publication details


Print publication date
28 Aug 2019
Copyright year
2019
Print ISBN
978-1-78801-433-5
PDF eISBN
978-1-78801-644-5
ePub eISBN
978-1-78801-869-2
From the book series:
Drug Discovery