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Chapter 15

Primary Drug Screening by In-cell NMR Spectroscopy

The successful application of in-cell NMR spectroscopy for primary drug high-throughput screening (HTS), by direct and indirect target engagement in prokaryotes is reviewed. We discuss approaches for identifying drug-binding targets, mapping the target interaction surface and methodologies to rapidly screen small-molecule libraries, as well as nascent strategies for primary drug HTS in eukaryotic cells, including novel methods of target and drug delivery to cells.

Publication details


Print publication date
13 Dec 2019
Copyright year
2020
Print ISBN
978-1-78801-217-1
PDF eISBN
978-1-78801-307-9
ePub eISBN
978-1-83916-093-6
From the book series:
New Developments in NMR