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Chapter 15

Primary Drug Screening by In-cell NMR Spectroscopy

The successful application of in-cell NMR spectroscopy for primary drug high-throughput screening (HTS), by direct and indirect target engagement in prokaryotes is reviewed. We discuss approaches for identifying drug-binding targets, mapping the target interaction surface and methodologies to rapidly screen small-molecule libraries, as well as nascent strategies for primary drug HTS in eukaryotic cells, including novel methods of target and drug delivery to cells.

Publication details

https://doi.org/10.1039/9781788013079-00249
Print publication date
13 Dec 2019
Copyright year
2020
Print ISBN
978-1-78801-217-1
PDF eISBN
978-1-78801-307-9
ePub eISBN
978-1-83916-093-6
From the book series:
New Developments in NMR