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Chapter 8

19F In-cell NMR

During the last decade 19F NMR has been developed as a popular tool for biomolecular NMR in living cells. Because there is no background perturbation, high sensitivity or large chemical shift dispersion, this spin-1/2 19F nucleus has been selectively incorporated into macrobiomolecules such as proteins and nucleic acids to study their conformation, interactions, and dynamics in a complex cellular environment. This chapter reviews 19F labeling methods for in-cell NMR and summarizes some of their applications in proteins and nucleic acid studies in cells.

Publication details


Print publication date
13 Dec 2019
Copyright year
2020
Print ISBN
978-1-78801-217-1
PDF eISBN
978-1-78801-307-9
ePub eISBN
978-1-83916-093-6
From the book series:
New Developments in NMR