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Chapter 8

19F In-cell NMR

During the last decade 19F NMR has been developed as a popular tool for biomolecular NMR in living cells. Because there is no background perturbation, high sensitivity or large chemical shift dispersion, this spin-1/2 19F nucleus has been selectively incorporated into macrobiomolecules such as proteins and nucleic acids to study their conformation, interactions, and dynamics in a complex cellular environment. This chapter reviews 19F labeling methods for in-cell NMR and summarizes some of their applications in proteins and nucleic acid studies in cells.

Publication details

Print publication date
13 Dec 2019
Copyright year
Print ISBN
ePub eISBN
From the book series:
New Developments in NMR