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Continuous Enantioselective Crystallization of Chiral Compounds

This chapter describes the possibility of attaining pure enantiomers through enantioselective crystallization. Focus is set on demonstrating options to realize separation processes operating continuously. Introductions are given to solid–liquid equilibria, the various types of phase diagrams of chiral systems, relevant kinetic phenomena, including metastable zones, and possible process options for batch and continuous separation of enantiomers. In the main part, results of case studies carried out in our laboratory are presented. Racemic mixtures of two conglomerates, namely D-/L-threonine and D-/L-asparagine monohydrate, were resolved by exploiting different variants of preferential crystallization, including two continuous operation modes.

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13 Feb 2020
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