All chapters

CHAPTER 6

Chemoenzymatic Synthesis of α-Dystroglycan O-Mannose Glycans

O-mannosylation is a conserved common post-translational modification of various eukaryotic proteins. The O-mannose glycans account for up to 30% of total O-glycans in mammalian brain tissues. However, the α-dystroglycan (α-DG) is the only O-mannosylated protein that has been extensively studied. This review covers the biosynthetic pathways and biological roles of O-mannose glycans, as well as the chemical and chemoenzymatic strategies developed for the synthesis of O-mannose core M1, core M2 and core M3 glycans.

Publication details

Print publication date
23 Apr 2019
Copyright year
2019
Print ISBN
978-1-78801-164-8
PDF eISBN
978-1-78801-657-5
ePub eISBN
978-1-78801-777-0

From the book series:
Chemical Biology