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CHAPTER 4

Chemical Synthesis of N-Glycans

Glycosylation is an important protein modification in nature that controls many biological processes. More than 50% of human proteins are glycosylated through asparagine residues. However, acquiring those N-glycans from natural sources is often laborious. Chemical synthesis, therefore, is a worthwhile alternative. This chapter summarizes recent advances in chemical synthesis, including strategies toward high-mannose type, hybrid type, complex type, N-acetylneuraminic acid (Neu5Ac)-containing, asymmetric, bisecting and core-fucosylated N-glycans.

Publication details

Print publication date
23 Apr 2019
Copyright year
2019
Print ISBN
978-1-78801-164-8
PDF eISBN
978-1-78801-657-5
ePub eISBN
978-1-78801-777-0

From the book series:
Chemical Biology