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CHAPTER 20

Protein Toxins as Antibody–Drug Conjugate (ADC) Payloads

Targeted therapeutics such as antibody–drug conjugates and immunotoxins represent a new era of therapeutic intervention aimed at improving patient outcomes by reducing off-target toxicities and increasing drug concentrations at the intended disease target. Targeted delivery of protein-based therapeutic payloads and biological-response-modifying proteins, like cytokines, provides another approach and therapeutic mechanisms to modify the tissue microenvironment. This chapter will focus on protein-based payloads that can be delivered with targeting agents, such as antibodies, antibody-like scaffolds, ligands or peptides.

Publication details

https://doi.org/10.1039/9781788012898-00427
Print publication date
15 Jul 2019
Copyright year
2019
Print ISBN
978-1-78801-077-1
PDF eISBN
978-1-78801-289-8
ePub eISBN
978-1-78801-845-6
From the book series:
Drug Discovery