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CHAPTER 12

Calicheamicins as Antibody–Drug Conjugate (ADC) Payloads

The calicheamicins are a class of naturally occurring DNA-damaging agents that were isolated and identified over 30 years ago. From the outset, it was recognized that the extreme cytotoxic potencies of members of this class of natural products precluded their use as stand-alone agents, but their potential utility as payloads for antibody–drug conjugates (ADCs) inspired researchers to search for the ideal calicheamicin derivative that could be successfully employed in this context. This chapter reviews the discovery of the calicheamicins and related compounds, the evolution of the so-called “AcBut-DMH–N-acetyl-calicheamicin” linker–payload used on Mylotarg™ and Besponsa™, the discovery of the related “DMA–N-acetyl-calicheamicin” derivative employed on another clinically relevant calicheamicin-based ADC, and ADCs bearing fully synthetic derivatives of calicheamicin θI1 that were accessed through reasonably efficient synthetic protocols.

Publication details

https://doi.org/10.1039/9781788012898-00259
Print publication date
15 Jul 2019
Copyright year
2019
Print ISBN
978-1-78801-077-1
PDF eISBN
978-1-78801-289-8
ePub eISBN
978-1-78801-845-6
From the book series:
Drug Discovery