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CHAPTER 13

Reproductive and Developmental Toxicity of Formaldehyde Exposure in Animals

The findings from our meta-analysis, described in Chapter 12, point to an association between maternal formaldehyde exposure and reproductive/developmental toxicity. This chapter will cover pertinent animal studies, providing biological support to the associations posed by the meta-analysis from human studies. The focus is on reproductive and developmental toxicity in rats and mice, among other animals; and, relevant exposure routes, markers of reproductive/developmental toxicity, postnatal toxicity, and ex vivo studies. The findings suggest a positive association between formaldehyde exposure and reproductive toxicity. Further studies assessing female reproductive toxicity and multigenerational reproductive toxicity are recommended.

Publication details


Print publication date
24 May 2018
Copyright year
2018
Print ISBN
978-1-78262-973-3
PDF eISBN
978-1-78801-026-9
ePub eISBN
978-1-78801-451-9
From the book series:
Issues in Toxicology