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CHAPTER 8

Formaldehyde Induced Leukemia-specific Chromosomal Aneuploidy

Although epidemiological evidence and toxicological studies support the association of formaldehyde and leukemia, to date, few studies have directly examined leukemia-specific changes on the causal pathways and have specifically targeted the hematopoietic stem/progenitor cells (HSCs/HPCs) of the exposed people. To address these critical issues, a molecular biomarker study was specially designed and conducted to explore the ability of formaldehyde to induce leukemia-specific chromosomal aneuploidy in the circulating HSCs/HPCs of exposed workers through two approaches: an initial approach and an expanded approach. The initial study primarily examined the formaldehyde-induced aneuploidy of chromosomes 7 and 8, frequently observed in leukemia patients. The expanded study employed a distinct chromosome-wide aneuploidy study (CWAS) approach to simultaneously evaluate aneuploidy of all 24 human chromosomes in the cultured circulating myeloid HSCs/HPCs of exposed but otherwise healthy Chinese workers. In this chapter, the findings and implications of both of the studies are detailed.

Publication details


Print publication date
24 May 2018
Copyright year
2018
Print ISBN
978-1-78262-973-3
PDF eISBN
978-1-78801-026-9
ePub eISBN
978-1-78801-451-9
From the book series:
Issues in Toxicology