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CHAPTER 5

Formaldehyde Carcinogenesis

Formaldehyde is a known human carcinogen for nasopharyngeal, sinonasal, and lymphohematopoetic cancers such as myeloid leukemia. In this chapter, the major epidemiologic studies that have demonstrated a causal link between formaldehyde and cancers are briefly discussed; and, the history of the classification of formaldehyde as a carcinogen is detailed. Additionally, the controversy surrounding formaldehyde’s carcinogenicity, particularly for formaldehyde-associated leukemia is deliberated; and, the major arguments against the formaldehyde–leukemia association are specifically outlined and briefly addressed one-by-one. Finally, this chapter is intended to serve as an introductory overview of the formaldehyde–leukemia association, which is further discussed in later chapters (Chapters 6–8) through a dissection of human epidemiologic studies and potential mechanisms of formaldehyde-associated leukemogenesis.

Publication details


Print publication date
24 May 2018
Copyright year
2018
Print ISBN
978-1-78262-973-3
PDF eISBN
978-1-78801-026-9
ePub eISBN
978-1-78801-451-9
From the book series:
Issues in Toxicology