Jump to main content
Jump to site search

All chapters
Previous chapter Next chapter

CHAPTER 4

General Toxicity of Formaldehyde

Over the past two decades, there have been many documented cases of acute and chronic toxicities in humans due to accidental formaldehyde exposure through polluted air, water, and contaminated food. Studies have revealed that the small, reactive aldehyde is toxic to the neural, immune and blood forming systems, and is also genotoxic. In this chapter, supporting evidence for formaldehyde-induced hematotoxicity in humans and animals are collectively summarized with a general review of a number of China-based studies. Additionally, genotoxicity, including the formation of DNA–protein crosslinks, DNA adducts, and chromosomal alterations, is described. Hematotoxicity and genotoxicity are most likely implicated in the basic molecular mechanisms of formaldehyde-induced leukemia and carcinogenesis.

Publication details


Print publication date
24 May 2018
Copyright year
2018
Print ISBN
978-1-78262-973-3
PDF eISBN
978-1-78801-026-9
ePub eISBN
978-1-78801-451-9
From the book series:
Issues in Toxicology