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Chapter 8

C–C Bond Formation in the Sustainable Synthesis of Pharmaceuticals

In this chapter, applications of transition metal-catalysed C–C coupling reactions with significance for the manufacture of active pharmaceutical ingredients (APIs) and other drug components in the pharmaceutical industry are presented. Currently, a vast number of biologically active compounds can be prepared under mild conditions from easily available substrates through cross-coupling reactions, highlighting their versatility, functional group tolerance and effectiveness. The C–C coupling reactions herein selected are those most commonly used as key steps in methodology design for the sustainable production of pharmaceuticals.

Print publication date: 28 Mar 2018
Copyright year: 2018
Print ISBN: 978-1-78262-934-4
PDF eISBN: 978-1-78801-065-8
ePub eISBN: 978-1-78801-441-0
Citation:
From the book series:
Green Chemistry Series