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Chapter 5

Applications of Catalytic Hydroformylation in the Synthesis of Biologically Relevant Synthons and Drugs

In this chapter, we highlight several aspects concerning the hydroformylation reaction, including the mechanism of rhodium-catalyzed hydroformylation (still considered the “metal of choice” due to its high activity and selectivity), the development and evolution of new metal catalysts and phosphorus ligands in a historical perspective, some strategies related to the synthesis of reusable catalysts for use in alternative media and the utilization of less toxic solvents and alternative metals. Finally, a set of selected examples of the applications of catalytic hydroformylation in the synthesis of relevant synthons and drug intermediates is presented.

Publication details

Print publication date
28 Mar 2018
Copyright year
Print ISBN
ePub eISBN

From the book series:
Green Chemistry Series