Injectable Nanogels in Drug Delivery
Development of simple and fast acting pharmaceutics that can be administered orally or as injectable forms has been a major concern for the pharmaceutical industries, but during last decades, this trend has changed to the development of effective formulations for efficient drug delivery. Non-degradation of drug carriers and reduced therapeutic potency of the drug before it reaches specific targets in the body are major challenges in contemporary drug delivery systems. Rather than discovering new drug molecules, which is expensive and time consuming, researchers are involved in improving the safety efficacy ratio of the existing drugs by designing efficient formulation that can target these drugs to specific sites and can control the drug delivery rate and period. A myriad of drug delivery systems, based on organic as well as inorganic materials, have been used to achieve this goal. Among these, nanogels, which are hydrogels in nanoscale dimensions, take over an important role in tackling the clinical and pharmacological limitations of current systems. The development of injectable nanogel systems can prevail over difficulties in the ease of application of hydrogel-based drug delivery system in clinic. In this chapter, we discuss nanogels, particularly on injectable nanogels, different polymers and various synthesis methods involved in their preparation, mode of action and their fate under physiological conditions. The chapter also discusses different applications of injectable nanogels with special reference to drug delivery and how these innovative class of system can reinstate our existing drug delivery systems.