Nanogels as Targeted Drug Delivery Vehicles
This chapter focuses on the recent advances in the research on nanogels as a carrier for targeted drug delivery. Nanogel structures enable easy attachment of vector groups for effective targeting to cells and desired targeted site. Recent years have witnessed an extraordinary expansion in drug delivery research in the area of targeted delivery. Nanogels as vehicles for targeting yield more effective therapies when most of the chemotherapeutics fail to show effect results clinically. Nanogels as drug delivery vehicles not only improve the therapeutic efficacy of the encapsulated drug but also reduce their side effects. Nanogels effectively communicate with several receptors for targeted drug delivery. These targeted therapies increase cancer cell sensitivity to chemotherapeutics by avoiding healthy cells and destroying resistant cells. The chapter critically discusses targeting of nanogels to various receptors such as integrin αvβ3, EphA2, folate, Hyaluronan and monoclonal antibodies.