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Chapter 13

Synthesis of Sulfonamides

Traditional and emerging methods for sulfonamide synthesis are discussed. As sulfonamides are typically accessed from sulfonyl chlorides, various approaches to sulfonyl chloride synthesis are included. Chlorosulfonylation of aromatic rings represents a reliable approach to sulfonyl chlorides, but requires hazardous reagents and is ineffective for electron-deficient substrates. Alternative approaches to sulfonyl chloride synthesis include the oxidation and chlorination of thiols, or the diazotization of anilines followed by treatment with sulfur dioxide. Additionally, the one-pot conversion of aryl halides to aryl sulfonamides via stoichiometric and catalytic organometallic intermediates is covered.

Publication details

Print publication date
01 Aug 2016
Copyright year
2016
Print ISBN
978-1-78262-786-9
PDF eISBN
978-1-78262-791-3
ePub eISBN
978-1-78262-792-0

From the book series:
Drug Discovery