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Chapter 12

C–N Bond Formation via Hydrogen Transfer

Traditional methods of C–N bond formation, such as reductive amination and amide coupling, involve the reaction of an amine with a reactive species, such as an aldehyde or activated carboxylic acid derivative. Recently, new methods utilizing catalytic alcohol dehydrogenation have been developed for the formation of C–N bonds. Such approaches, known as “borrowing hydrogen” and “acceptorless dehydrogenation”, permit C–N bond formation by the direct coupling of amines with alcohols, without preactivation. This chapter describes N-alkylation, amide coupling, and heterocycle synthesis enabled by metal-catalyzed alcohol dehydrogenation.

Publication details

Print publication date
01 Aug 2016
Copyright year
2016
Print ISBN
978-1-78262-786-9
PDF eISBN
978-1-78262-791-3
ePub eISBN
978-1-78262-792-0

From the book series:
Drug Discovery