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CHAPTER 13

Peptide Therapeutics: Neuropeptides

The development of neuropeptide therapeutics poses several difficulties, including stability, bioavailability, receptor selectivity, and the ability (or not) to cross membrane barriers. In this chapter we discuss briefly the efforts that are being made to address these problems using selective examples for the melanocortin, bradykinin and opioid systems. The use of conformational constraint, topographical constraint, and computational approaches to ligand design, including ligand–receptor homology modeling are discussed as an approach to enhance the properties of peptides for the development of peptide therapeutics.

Publication details


Print publication date
26 Jun 2017
Copyright year
2017
Print ISBN
978-1-78262-732-6
PDF eISBN
978-1-78801-153-2
ePub eISBN
978-1-78801-171-6
From the book series:
Drug Discovery