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Chapter 1

Practical Approaches for In Situ X-ray Crystallography: from High-throughput Screening to Serial Data Collection

In situ data collection for macromolecular crystallography has undergone rapid development in the last decade. From routine crystal hit screening in X-ray-friendly SBS-format plates to serial data collection in dedicated setups, its field of application has expanded significantly. The in situ approach has benefitted from progress in beamline instrumentation and automation and from new modes of sample delivery, inspired by serial crystallography using X-ray free-electron lasers. In this review, the various in situ methods available at synchrotron facilities are described with a view to enabling users to make informed decisions regarding their applicability in structural biology or drug discovery projects.

Publication details


Print publication date
21 Jun 2018
Copyright year
2018
Print ISBN
978-1-78262-728-9
PDF eISBN
978-1-78801-050-4
ePub eISBN
978-1-78801-477-9
From the book series:
Chemical Biology