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Chapter 7

Enhancing Enzymatic Performance via Restricted Sequence Space Approaches

Protein engineering reflects the active design of protein properties by changing its amino acid sequence. This goal can be approached via rational design, combinatorial design, or a combination, termed data-driven protein engineering. Among the two principal strategies of tackling the huge size of protein sequence space, this chapter focuses on restricting the sequence space rather than on increasing the library size. Efficient variant generation can be achieved both by picking a limited number of residues to be mutated as well as by restricting the set of amino acid residues to code for.

Publication details

Print publication date
31 May 2018
Copyright year
Print ISBN
ePub eISBN
From the book series:
Catalysis Series