Application of Molecular Modelling to Speed-up the Lead Discovery Process
By transforming many life-threatening diseases to almost negligible problems, drug discovery has improved life expectancy and our quality-of-life in general. However, in recent years, the flat trend of new drugs reaching the market, coupled with the increase of costs of this long process has led the pharmaceutical sector to a ‘crisis’. For this reason, research and development has turned to cutting-edge technology to reduce time and expense. In this chapter, we will discuss how the impressive improvements in both structure- and ligand-based molecular modelling approaches can help to drive and speed up drug discovery, making important contributions at all levels of the process.