Synthesis of molecularly imprinted polymers (MIPs) using macromolecular templates (Mw > 1.5 kDa), and proteins in particular, is highly demanding. So it is no wonder that this issue has attracted significant attention for nearly last two decades, especially in the field of selective chemosensor devising. Despite an extensive research effort in this field, there had been only a limited progress made till the beginning of the present decade. New approaches and new ideas that were proposed in the last few years raised protein imprinting to a completely new level. This progress prompted us to prepare a comprehensive overview of the research accomplished toward devising MIP based chemosensors for selective protein determination.