Molecularly Imprinted Polymers-based Separation and Sensing of Nucleobases, Nucleosides, Nucleotides and Oligonucleotides
Modified nucleosides have become cornerstones of treatment for patients with cancer or viral infections. Moreover, they are excreted in the urine of cancer patients in high levels and are considered to be potential tumor biomarkers. ATP and its analogues play an important role in several functions of the cardiovascular system. Moreover, circulating nucleotides have therapeutic importance on the progression of metabolic disorders. Thus, their detection and quantization are important. To gain in selectivity, the design of artificial polymer receptors, so-called molecularly imprinted polymers (MIPs) that can selectively recognize nucleotide bases, has gained importance from the theoretical application point of view. We will initially review the articles that are interested in the development of MIPs for the recognition of nucleoside analogues. Then, the second part of the chapter will describe the work published on the use of MIPs in the field of separation techniques and sample pretreatment. The final part will summarize research where the MIP technology can improve the analytical selectivity of the sensors of all types.