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Smart Functional Porous Materials for Tissue Engineering

A high incidence of joint diseases in the aging population, long-term pain and disability, and the economic burden of the illness call for more effective treatment strategies. Hence, restoration of the diseased cartilage and bone in individuals suffering from osteoarthritis has a considerable appeal for clinicians and researchers. The success of tissue engineering for the treatment of joint diseases highly depends on the ability to create a favorable microenvironment at the repair site and to support and induce new tissue formation. This can be partially achieved by the design of tissue-specific three-dimensional (3D) scaffolds with controlled micro-/nanoscale features resembling the extracellular matrix (ECM) of native tissues. This chapter presents an overview of the recent developments in the design of functional scaffolds for bone and cartilage tissue engineering. First, the ongoing efforts in designing bioinspired materials have been briefly discussed. The main body of the chapter covers some of the recent strategies for the development of hierarchical and multiphasic scaffolds to mimic the ECM of biological tissues. Moreover, this chapter reports a few studies undertaken to improve the in vivo vascularization potential of 3D scaffolds through microarchitecture design. A summary of existing challenges has been discussed in the concluding section of this chapter.

Publication details

Print publication date
13 Dec 2016
Copyright year
Print ISBN
ePub eISBN
From the book series:
Smart Materials Series