Functional Nucleic Acid Incorporated Materials for Cell Therapy and Tissue Engineering
Delivery of nucleic acids with polymeric nanomaterials is an ongoing area of research that has great potential to treat diseases for which cures have remained mostly elusive. These technologies can be used for stem cell gene modification, overexpression of therapeutics, precise control over cell fate and differentiation to specific lineages. In addition, integrating such advanced nanomaterials with tissue engineering platforms enhances modified stem cell survival, proliferation, and regenerative capacity. Overall, this chapter seeks to describe the current types of nanomaterials, including viruses, and nucleic acids and evaluate their use in combination with stem cells. The chapter also underscores the recent developments pertaining to their characterisations and applications in tissue engineering and regenerative medicine.