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CHAPTER 9

Mitochondria-Targeted Rechargeable Antioxidants as Potential Anti-Aging Drugs

Initially regarded solely as “power plants of the living cell”, mitochondria are now also acknowledged as key regulators of cell survival, death, and ageing. Mitochondrial malfunction correlates with aging in a broad variety of species, including yeast, invertebrates and mammals. An important consequence of the mitochondrial malfunction is an increase in the level of reactive oxygen species (ROS). Excessive level of mitochondrial ROS (mROS) results in imbalance of regulatory mitochondrial pathways, oxidative stress, and cell death, which triggers several age-related pathologies. Mitochondria-targeted rechargeable antioxidants (e.g. SkQ1, SkQR, MitoQ) are promising candidates for development of therapeutic drugs capable of suppressing mitochondria-initiated oxidative stress and thereby promoting healthy aging and longevity. In this review, we focus on the studies of mitochondria-targeted rechargeable antioxidants in animal models, with a special focus on experiments with Drosophila melanogaster.

Publication details


Print publication date
01 Feb 2017
Copyright year
2017
Print ISBN
978-1-78262-435-6
PDF eISBN
978-1-78262-660-2
ePub eISBN
978-1-78262-985-6
From the book series:
Drug Discovery