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Structure and Function of Nitric Oxide Reductases

Nitric oxide reductase (NOR) is a key enzyme in denitrification, since it contributes to the decomposition of highly cytotoxic NO, which is generated as an intermediate compound from NO2 catalysed by nitrite reductase. Bacterial NOR is a membrane-integrated enzyme that contains iron in its active site and catalyses the NO reduction as follows: 2NO + 2H+ + 2e → N2O + H2O. First crystal structures of cytochrome c-dependent NOR from Pseudomonas aeruginosa and then that of quinol-dependent NOR from Geobacillus stearothermophilus were reported in 2010 and 2012, respectively. In this chapter, molecular and functional properties of NORs are described on the basis of these structures.

Print publication date: 15 Nov 2016
Copyright year: 2017
Print ISBN: 978-1-78262-334-2
PDF eISBN: 978-1-78262-376-2
ePub eISBN: 978-1-78262-926-9
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