Jump to main content
Jump to site search
SCHEDULED MAINTENANCE Close the message box

Maintenance work is planned for Monday 16 August 2021 from 07:00 to 23:59 (BST).

Website performance may be temporarily affected and you may not be able to access some PDFs or images. If this does happen, refreshing your web browser should resolve the issue. We apologise for any inconvenience this might cause and thank you for your patience.

All chapters

Synthetic extracellular matrix approaches for the treatment of myocardial infarction

Injectable biomaterials, that mimic one or more functions of the natural extracellular matrix (ECM), are used in therapies that aim at improvement of cardiac repair and induction of regeneration of the heart. In this chapter we discuss recent trends in synthetic ECM approaches using injectable biomaterials to repair and regenerate the heart, and relate this to the design criteria to truly mimic (parts of) the natural ECM in a synthetic way. To fully understand the design criteria we first discuss the healthy and adverse remodeled cardiac niche in which the ECM and soluble factors play important roles. Additionally, knowledge of the remodeling processes and cardiac performance post-myocardial infarction is needed. Finally, we review various synthetic ECM approaches for the treatment of the infarcted heart; i.e. (i) hydrogels that support the myocardial matrix via mechanical and/or bioactive cues, (ii) hydrogel materials that release bioactive factors, (iii) materials that deliver cells, and (iv) hydrogel materials that induce cell recruitment.

Publication details

Print publication date
29 Nov 2017
Copyright year
Print ISBN
ePub eISBN
From the book series:
SPR - Synthetic Biology