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Protein scaffolds and higher-order complexes in synthetic biology

Interactions between proteins control molecular functions such as signalling or metabolic activity. Assembly of proteins via scaffold proteins or in higher-order complexes is a key regulatory mechanism. Understanding and functionally applying this concept requires the construction, study, and utilization of synthetic scaffolds. This chapter first describes protein scaffolding in the context of its natural function as well as the underlying mechanistic origins via mathematical models and simulations. This is then funnelled into examples of synthetic biology approaches to engineer new scaffolds and their usage as regulators of signalling networks and metabolic engineering.

Publication details


Print publication date
29 Nov 2017
Copyright year
2018
Print ISBN
978-1-78262-120-1
PDF eISBN
978-1-78262-278-9
ePub eISBN
978-1-78801-405-2
From the book series:
SPR - Synthetic Biology