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Design and applications of synthetic information processing circuits in mammalian cells

Mammalian cells represent a challenge and opportunity for synthetic biology. The toolbox of regulators implemented in mammalian cells includes small molecule- or physical stimulus-responsive elements from bacteria, yeast and plants, and designed nucleic acid binding proteins such as TALEs and CRISPR/Cas. This enables engineering of mammalian cells to sense versatile external or endogenous signals and process them via designed logic circuits, or rewiring of endogenous signaling pathways for therapeutic responses, demonstrated in disease models of diabetes, inflammation, cancer… Synthetic biology tools are also applied to improve safety and efficiency of engineered therapeutic cells, such as for cancer immunotherapy or stem cells.

Publication details


Print publication date
29 Nov 2017
Copyright year
2018
Print ISBN
978-1-78262-120-1
PDF eISBN
978-1-78262-278-9
ePub eISBN
978-1-78801-405-2
From the book series:
SPR - Synthetic Biology