All chapters

CHAPTER 6

Enzymes of the Xanthine Oxidase Family

Enzymes from the xanthine oxidase (XO) family of molybdenum enzymes are generally, with some exceptions, molybdenum iron–sulfur flavin hydroxylases. Mammalian xanthine oxidoreductase and aldehyde oxidase were among the first enzymes to be studied in detail more than 100 years ago and, surprisingly, they continue to be thoroughly studied in molecular detail with many open and unresolved questions remaining. Enzymes of the XO family are characterized by a molybdenum cofactor (Moco) active site with a MoVIOS(OH) ligand sphere where substrate hydroxylation of either aromatic or aliphatic carbon centers is catalyzed. During the reaction, electrons are transferred to the oxidizing substrate, most commonly O2 or NAD+, which react at the FAD site.

Publication details

Print publication date
28 Sep 2016
Copyright year
2017
Print ISBN
978-1-78262-089-1
PDF eISBN
978-1-78262-391-5
ePub eISBN
978-1-78262-881-1

From the book series:
Metallobiology